- Can trigger a metabolic switch from glucose-based to ketone-based energy
- Increased longevity
- Decreased incidence of diseases
- Including cancer and obesity
Metabolic switch
- Focus on the physiological responses of major organ systems
- Including musculoskeletal system
- The point of negative energy balance
- First
- Liver glycogen stores are depleted
- Second
- Fatty acids are mobilized (typically beyond 12 hours after cessation of food intake)
- First
- Glucose to fatty acid-derived ketones
- Shifts metabolism
- From
- Lipid/cholesterol synthesis and fat storage
- To
- Mobilization of fat through fatty acid oxidation and fatty-acid derived ketones, which serve to preserve muscle mass
- From
Intermittent fasting induces metabolic switch
- Have the potential to improve body composition in overweight individuals
- Induce the coordinated activation of signaling pathways that
- Optimize physiological function
- Enhance performance
- Slow aging and disease processes
Reducing food availability over a lifetime (caloric restriction) has remarkable effects on aging
- Health benefits of caloric restriction result from a passive reduction in the production of damaging oxygen free radicals
- The magnitude of the effect of intermittent fasting on life-span extension is variable and influenced by
- Gender
- Diet
- Genetic factors
Fasting period
- Triglycerides are broken down to fatty acids and glycerol, which are used for energy
- Liver converts fatty acids to ketone bodies
During feeding period
- Cells engage in tissue specific processes
- Growth
- Most people consume three meals a day plus snacks
- Intermittent fasting does not occur
- Glucose and fatty acids are the main sources of energy for cells
- After meals
- Glucose is used for energy
- Fat is stored in adipose tissue as triglycerides
- In the fed state, blood levels of ketone bodies are low, they rise within 8 to 12 hours after the onset of fasting
Health benefits of intermittent fasting
- Weight loss
- Improves glucose regulation
- Increases stress resistance
- Suppresses inflammation
Fasting period: cells activate pathways
- Enhance intrinsic defenses against oxidative and metabolic stress
- Removes or repairs damaged molecules
- Obesity
- Diabetes
- Cardiovascular disease
- Cancers
- Neurodegenerative brain diseases
- Greater metabolic flexibility and efficiency of energy production from fatty acids and ketone bodies
- An alternative source of energy supply produced from fatty acids by the liver during periods of caloric restriction
- Used as an energy source when glucose is not readily available
- Not just fuel used during periods of fasting
- Potent signaling molecules with major effects on cell and organ functions
- Influences health and aging
- Fat cells release stored fatty acids, to be used as energy (facilitates fat burning)
- Occurs when insulin levels drop for long enough
What are the health risks of eating a flexitarian diet?
- Decreased meat consumption can lead to micronutrient deficiencies
- Vitamin B12
- Zinc
- Calcium
Overview: Our recommendations
- Whole food diet
- Mediterranean diet with time restricted eating
- Individuals with health conditions
- Consult with healthcare practitioner for specific dietary recommendations
DISCLAIMER
This information is intended for educational purposes only and it is not intended to take the place of consultation with your physician.
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